Companion diagnostic technology to be utilized with enasidenib (AG-221/CC-90007) and AG-120 development programs for relapsed/refractory acute myeloid leukemia (AML)
Approximately 20% of AML patients have an IDH mutation
IDH1 and IDH2 mutations occur in approximately 20% of AML patients. An article published online this week in the journal Leukemia (Medeiros, Leukemia 2016) concluded that advances in the understanding of the genetics underlying myeloid malignancies are driving an era of development for targeted treatments such as IDH mutant inhibitors. The authors recommend that IDH mutational analysis should become part of the routine AML diagnostic workup and repeated at relapse to identify patients who may be eligible for targeted investigational treatments currently under clinical study.
"AML is a complex and heterogeneous disease, making it difficult to
Abbott's m2000rt RealTime System, is a polymerase chain reaction
(PCR) instrument designed to enable clinical laboratories to automate
PCR and results analysis, simplifying the complex and manual steps often
associated with molecular diagnostics. Both
"The field of personalized medicine is advancing at a rapid pace for a
broad range of medical conditions, especially within
The m2000 system has not been
Enasidenib and AG-120 have not been approved for any use in any country.
Agios is focused on discovering and developing novel investigational medicines to treat cancer and rare genetic metabolic disorders through scientific leadership in the field of cellular metabolism. In addition to an active research and discovery pipeline across both therapeutic areas, Agios has multiple first-in-class investigational medicines in clinical and/or preclinical development. All Agios programs focus on genetically identified patient populations, leveraging our knowledge of metabolism, biology and genomics. For more information, please visit the company's website at www.agios.com.
This press release contains forward-looking statements, which are
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"believes," "intends," "estimates," "plans," "will," "outlook" and
similar expressions. Forward-looking statements are based on
management's current plans, estimates, assumptions and projections, and
speak only as of the date they are made. Neither
Senior Director, Investor & Public Relations
Senior Manager, Investor & Public Relations
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