Survey provides a unique and comprehensive look at patient quality of life
Nearly half of psoriasis patients surveyed had not seen a doctor in the past year and two-thirds of psoriatic arthritis patients surveyed were not receiving medical treatment for their condition
Results suggest need for greater awareness, improved assessment tools, better communication between physicians and patients, and new treatments
The Multinational Assessment of Psoriasis and Psoriatic
Arthritis (MAPP) survey is the largest comprehensive survey of its kind.
"For decades, healthcare providers have been searching for ways to help
these psoriasis and psoriatic arthritis patients live more productive
lives in spite of their diseases," said
Despite Disease Burden, Patients Forgo Treatment; Patients Call for New Treatment Options
The survey highlighted the need for safe and effective therapies for patients with psoriasis and PsA. The survey also found that a large number of both psoriasis and PsA patients were either being undertreated or were not receiving doctor-prescribed treatments.
A large majority (85 percent) of patients surveyed stated that there was a need for better therapies. Nearly 60 percent of PsA patients surveyed stated that they were not receiving any treatment, and the majority of psoriasis patients with 4 percent or more of their body surface area (BSA) covered by psoriasis were receiving no treatment or only topical therapy.
Many patients had been prescribed a traditional oral or biologic medication at some point but had stopped using it (57 percent of patients given a traditional oral and 45 percent of those given a biologic). The most common reasons for discontinuation were safety and tolerability issues or lack/loss of efficacy.
About half of psoriasis and PsA patients who had received traditional oral medications found these therapies burdensome. Similarly, about half indicated that biologics were also burdensome. In addition, patients also had anxiety/fear of injections and physical preparation for self-injection.
Impact on Disease-Related Quality of Life for Psoriasis and PsA Patients is Significant
Results from the
Psoriatic arthritis patients with more than four affected joints responded that they had experienced "much difficulty" or were "unable to do" ordinary daily tasks such as bending down to pick up clothing from the floor (26 percent) and dressing themselves (15 percent) to getting in and out of bed or the car (15 percent) and washing and drying their body (12 percent).
A Gap Between Healthcare Provider and Patient Assessment of Disease Severity Reported
The authors noted that results suggest there is a disconnect between the way patients and physicians define severity.
For example, itching (pruritus) was the most commonly reported symptom among all patients, and was cited by 43 percent of psoriasis patients and 40 percent of PsA patients as the most bothersome symptom, but itching is rarely captured by assessment tools. Itching (38 percent) and location and size of skin lesions (17 percent) were the most important factors contributing to disease severity in patients with psoriasis.
"Determining the severity of psoriasis and psoriatic arthritis is
difficult because health care providers often focus on elements that are
easily measured, such as the size of the psoriasis lesions or the number
of joints affected. However, severity should also include impact on
quality of life," said
Psoriasis is an immune-mediated, non-contagious chronic inflammatory
skin disorder of unknown cause. The disorder is a chronic recurring
condition which varies in severity from minor localized patches to
complete body coverage. Plaque psoriasis is the most common type of
psoriasis. About 80 percent of people who develop psoriasis have plaque
psoriasis, which appears as patches of raised, reddish skin covered by
silvery-white scales. These patches, or plaques, frequently form on the
elbows, knees, lower back, and scalp. Psoriasis occurs nearly equally in
males and females. Psoriasis is believed to be most common in Caucasians
and slightly less common in other ethnic groups. Worldwide, psoriasis is
most common in Scandinavia and other parts of northern
About Psoriatic Arthritis
Psoriatic arthritis is a painful, chronic inflammatory disease characterized by pain, stiffness, swelling and tenderness of the joints, inflammation of specific ligaments and tendons and decrease in physical functioning. It is estimated that nearly 38 million people worldwide have psoriatic arthritis. Psoriatic arthritis can impact day-to-day activities and has been reported to increase work disability. Common signs and symptoms of psoriatic arthritis include pain, stiffness and swelling in joints. To learn more about psoriatic arthritis, go to www.discoverpsa.com.
Celgene International Sàrl, located in Boudry,
Vice President, Investor Relations
Director, Corporate Communications
Source: Celgene International Sàrl
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